What is serological conflict? Prevention and diagnosis

Discover the risks and preventive measures of serological conflict during pregnancy. This issue, caused by differences in blood group antigens between mother and baby, can lead to severe complications if left untreated. Learn how regular testing and interventions for Rh-negative women can save lives, including affordable options in Poland. Share this informative article with expectant mothers to ensure a healthier pregnancy experience!
What is serological conflict
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Serological conflict is a problem in pregnancy that can cause issues between a mother’s and baby’s blood types. This issue was more common in the 1990s when there were fewer diagnostic and therapeutic methods available, leading to many infant deaths during pregnancy or shortly after birth. Although still important, effective prevention for this condition has made great strides in recent years.

Serological conflict occurs when there is a difference in blood group antigens between the mother and fetus. The most common discrepancy involves the D antigen from the Rh system, but it can also occur with other antigens such as C, E, Kell, MNSs, Kidd, Duffy and ABO systems. When microleakages happen between the mother’s and fetus’ blood during each pregnancy – which is normal – antibodies produced by the woman against her baby’s cells pass through to combine with their own cells causing destruction (hemolytic disease of newborn). If left untreated or undiagnosed early on, this can result in severe complications including intrauterine death or birth of an extremely ill child.

Affecting approximately 0.2-0.3% of all pregnancies worldwide according to estimates today; however advancements like routine tests for pregnant women checking for antibodies targeting red blood cell components have significantly decreased cases of serious consequences due to serological conflict over time. Pregnant women should be tested for their specific blood groups at regular intervals throughout their gestation period – especially those who are Rh-negative since they carry an increased risk – along with assessing whether any immune antibodies exist within them before receiving appropriate interventions if needed such as anti-D immunoglobulin administration midway through pregnancy(between week 28-30)to prevent future sensitization towards potential threats resulting from serologial conflicts .
After giving birth, Rh-negative women need another anti-D immunoglobulin dose to protect them during future pregnancies. This should be done within 3 days post-delivery or after a miscarriage, ectopic pregnancy removal, invasive diagnostics, or heavy bleeding during pregnancy. For each new pregnancy, this preventative measure must be repeated.

In Poland, state healthcare recommends and covers the cost of this prevention for Rh-negative pregnant women between weeks 28 and 30 following an antibody test. Private purchase costs around PLN 400.

Fetal genotyping is a non-invasive diagnostic technique that can detect the child’s Rh blood type using their mother’s blood sample and looking for the D antigen in it before birth. Women with Rh-negative children are exempt from needing prophylaxis treatment but may require extra payment or access it through clinical trials currently.

Nicola (an individual): I am Rh negative; Kuba (her partner) wasn’t aware of his blood type until our son was born Rh positive at week 28—I got an injection then despite Roger being born as an Rh negative which might not have necessitated the treatment theoretically but I still chose to do so again!

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